Changes in version 0.1.1                        

  - Send upload config_yaml as inline YAML text, matching the current
    API form contract.
  - Add wrappers for report creation, model-fit postprocessor status,
    dosing-input status, fit simulation-job listing, and simulation
    from-text creation endpoints.
  - Fix examples to use valid time bases and clarify that OpenAPI
    codegen is not shipped yet.

                        Changes in version 0.1.0                        

First broadly functional release: the client now covers the full
analysis workflow — treatments, studies, datasets/prep, data-versions,
modeling-data tables, NCA, modeling (build runs + fits + estimates),
simulation, and the study analysis log — with typed S3 objects, tibble
collections, async polling, and classed errors, all validated against
the real API (staging). Known deferred pieces: the nlmixr2/Torsten data
adapters, vmx_dataset_download, and tibble reshaping of the VPC artifact
(each needs real-data validation).

  - Analysis log: vmx_analysis_log() (GET /studies/{id}/analysis-log,
    paginated → tibble; since accepts a POSIXct/Date or ISO-8601 string;
    resource accepts an id or object).
  - Diagnostics: vmx_fit_obs_vs_pred() now reshapes the PK observation
    block into a one-row-per-observation tibble (predicted-concentration
    bands on the "extra" attribute, PD block on "pd"). vmx_fit_vpc()
    still returns the parsed nested artifact.

Development history (0.0.0.9000)

  - Initial package skeleton: directory layout, public API surface
    (stubs), vmx_client() connection object with redacted-token
    printing, the vmx_error condition hierarchy, and the design proposal
    under docs/.
  - Phase 0 (GEN-2257): real httr2 HTTP layer — bearer auth,
    {error:{...}} envelope mapping onto vmx_auth_error/vmx_api_error,
    and next_cursor pagination. Implemented vmx_whoami(), vmx_health(),
    the vmx_treatments() / vmx_treatment() / vmx_treatment_create() /
    vmx_treatment_update() verbs, vmx_upload() (streamed multipart),
    vmx_prep_status(), and vmx_wait() (dataset/prep-status poller).
    Typed S3 resource objects with print/as_tibble, id-or-object
    resolution with prefix validation, and collection→tibble conversion.
    httr2-mocked unit tests plus an opt-in live smoke test
    (VMX_RUN_LIVE_TESTS=1).
  - Studies + data-versions slice: vmx_studies() / vmx_study() /
    vmx_study_create() / vmx_study_update(); vmx_data_versions() /
    vmx_data_version() / vmx_data_version_create() (format job over an
    upload composition, returns a prep-status) /
    vmx_data_version_archive() / vmx_data_version_unarchive() /
    vmx_data_version_export() (signed-URL envelope, optional streamed
    download). Adds a vmx_patch() HTTP helper and vmx_opt_id()
    (NULL-passthrough id resolution). The vmx_data_version_table() and
    modeling-data adapters (§6.5a) remain stubbed for a dedicated slice.
  - NCA slice: vmx_nca_analyses()
    (data-version/study/treatment/status/time-basis filters), vmx_nca()
    (create + optionally block via vmx_wait()), vmx_nca_get(), and
    vmx_nca_result() (reshapes point_estimates into a tidy
    one-row-per-subject tibble, quantity metadata on the "quantities"
    attribute). vmx_wait() gains an NCA method (terminal
    completed/degraded succeed, failed raises). The status poller is
    refactored into a generic vmx_poll_status() shared by the dataset
    and NCA waiters.
  - Modeling slice: vmx_model_catalog() (categories flattened to a
    tibble), vmx_model_describe(), vmx_modeling_options();
    vmx_model_build() (parses the "GEN_uuid:increasing" pd-marker
    shorthand, create + optional vmx_wait()), vmx_model_build_runs() /
    _status() / _results() / _logs() / _export() / _report() /
    _cancel(); and fits: vmx_model_fits(), vmx_model_fit() (details),
    vmx_fit_subject_estimates() and vmx_fit_global_estimates() (reshaped
    to tidy tibbles with point estimate + credible interval). vmx_wait()
    gains a model-build-run method (terminal succeeded/degraded succeed;
    failed/cancelled raise). The vmx_nca() / vmx_model_build() wait =
    TRUE paths now forward polling controls (timeout/interval/progress)
    to vmx_wait(). vmx_fit_obs_vs_pred() and vmx_fit_vpc() return the
    parsed diagnostic artifacts as-is for now; reshaping their nested
    plot bands into tibbles is a follow-up.
  - Simulation slice: vmx_dosing_input(); vmx_sim_existing_subject(),
    vmx_sim_hypothetical_subject(), vmx_sim_population() (accept a
    data.frame of subjects/covariates or explicit records; create +
    optional vmx_wait()); vmx_sim_status(), vmx_sim_result(),
    vmx_sim_cancel(). vmx_wait() gains a simulation-job method (terminal
    succeeded; failed/cancelled raise). vmx_sim_result() returns the
    parsed result payload (reshaping deferred).
  - Dataset + prep verbs: vmx_dataset_files(), vmx_dataset_tags()
    (key/value tibble), vmx_dataset_cancel(), vmx_upload_ignore() /
    vmx_upload_unignore() (now take dataset + upload),
    vmx_prep_questions() (prompt fields → tibble), and vmx_prep_answer()
    (posts a named-list answers body). vmx_dataset_download() stays
    unimplemented — the files listing exposes no per-file download URL
    (use vmx_data_version_export()).
  - Modeling-data access: vmx_data_version_table() (any of the
    subjects/pk/ dosing/pd/labs/covariates domains → a typed tibble,
    column metadata on the "columns" attribute), the vmx_subjects() /
    vmx_pk() / vmx_pd() accessors, and vmx_model_data() (bundles the
    available tables + DV metadata as a vmx_model_data object, fetching
    only table_availability domains). The nlmixr2 (vmx_nlmixr_data())
    and Stan/Torsten (vmx_torsten_data()) adapters remain deferred stubs
    — the NONMEM/ragged-array assembly must be validated against real
    data + the DV column manifest before shipping.